THE TRUE IDENTITY OF AMṚTOTTARAM KAṢĀYAM: EARLY MANUSCRIPT EVIDENCE ON THE RATIO OF INGREDIENTS
Published in January-March 2026 (Vol. 2, Issue 1, 2026)

Abstract
Authors (2)
Madhu Koythodi Parameswaran
Associate Professor, Vaidyaratnam P S Varier Ayurveda College Kottakkal
View all publications →Sandrima Priya Sanjeevan
Post Graduate Scholar, Vaidyaratnam P S Varier Ayurveda College, Kottakkal
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Article Information
Published in:
January-March 2026 (Vol. 2, Issue 1, 2026)- Article ID:
- KJAMR120054
- Paper ID:
- KJAMR-01-000054
- Published Date:
- 2026-01-27
How to Cite
Koythodi, M. & Priya, S. (2026). THE TRUE IDENTITY OF AMṚTOTTARAM KAṢĀYAM: EARLY MANUSCRIPT EVIDENCE ON THE RATIO OF INGREDIENTS. Kottakkal Journal of Ayurvedic Medicine And Research, 2(1), xx-xx. https://kjamr.scholarjms.com/articles/26
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Roga pareeksha and Rogi pareeksha constitute the two primary diagnostic components of Ayurveda. Nidana panchaka—comprising Hetu, Purvaroopa, Roopa, Upashaya-Anupashaya & Samprapti - serves as a comprehensive diagnostic framework for understanding the modalities of roga pareeksha. Among these, Upashaya and Anupashaya exemplify a trial-and-error approach applied prior to definitive diagnosis and treatment selection. The Upashaya method is particularly valuable when clinical symptoms overlap, aiding in differential diagnosis through therapeutic testing. Administration of Ahara, Vihara, or Aushadha that acts contrary to the Hetu, Vyadhi, or Hetu-Vyadhi is termed Vipareeta upashaya, whereas the approach that aligns with them is known as Vipareetartakari upashaya. Though the concept of vipareetarthakari upashaya appears complex, our Acharyas have provided clear rationales to justify its therapeutic relevance. A classical example is the advocacy of jalapratarana in urusthambha, an application of hetu-vyadhi vipareetarthakari vihara upashaya. Urusthambha is a disorder best managed through Ayurvedic shamana aushadhis. However, jalachankramana chikitsa as described by Acharya Charaka proves particularly effective by facilitating the vilayana of accumulated meda dhatu in the uru pradesha, thereby restoring the normal function of avruta vata. Pathologically, Urusthambha can be correlated with lipid myopathies, wherein adiponectin and endothelin-1 play crucial roles. Adiponectin exerts a protective effect by promoting fatty acid oxidation and reducing lipid accumulation in muscle cells, suggesting its potential as a novel therapeutic target for myopathies. Interestingly, studies indicate that cold-water swimming elevates adiponectin levels, thereby imparting beneficial effects on the musculoskeletal system. Moreover, combined interventions such as whole-body cryotherapy and cold-water swimming are known to elevate HDL levels while reducing LDL and total cholesterol. Experimental studies on animal models further support the beneficial effects of swimming exercise in mitigating myopathies via reducing ET-1, enhancing vascular function and decreasing ET-1 mediated vasoconstrictor tone.
AYURGENOMICS - UNIFYING ANCIENT CONCEPTS WITH GENETIC INSIGHTS
Background: Genomics has ushered in a new era of predictive, preventive and personalized medicine. Ayurveda and similar medical systems evolved on traditional scientific principles has long emphasized a personalized approach to health and disease management. Integrating the principles of Ayurveda with advances in genomics, as Ayurgenomics holds the potential to bridge this gap and enhance personalized healthcare. Methods: Online databases: Medline, Pubmed, Embase, AMED, CAMbase and Google Scholar were searched with key words ‘Prakriti’, ‘genomics’, ‘Ayurgenomics’, ‘epigenetics’, ‘Ayurveda’, ‘precision medicine’, ‘personalized medicine’, ‘integrated medicine’ and ‘review’ separately and in combination using appropriate Boolean operators AND and OR. Results: Original research articles selected based on keywords were screened for relevancy, redundancy, English language, full text and repetitions. There was a growing trend in incorporating newer molecular techniques in identifying Prakriti in publications. All relevant clinical trials were included. Findings indicate distinct genetic signatures associated with Prakriti. Certain SNPs including those in gene related to immunity, metabolism and inflammatory regulation have been associated with specific Prakriti types. Collectively, these findings substantiate the hypothesis that Prakriti has a genetic basis reflecting both innate constitution and disease susceptibility. Conclusions: Genomic studies on Prakriti provide a scientific foundation for Ayurveda’s personalized approach to health and disease. Establishing robust correlation between genes and Prakriti could transform healthcare by enabling tailored preventive and therapeutic strategies. Larger multi ethnic studies employing advanced omics tools are required to strengthen evidence and enhance the integration of Prakriti based frameworks with modern precision medicine.
REDEFINING THE KERALA MODEL RITU SODHANA- BRIDGING PRINCIPLE WITH PRACTICE
Introduction Ayurveda emphasizes specific regimens tailored to each season, known as Ritucharya. Despite their proven efficacy in maintaining health and preventing diseases exacerbated by seasonal imbalances (Sanchaya Poorvaka Prakopa of Dosa), these traditional practices are often overlooked in contemporary healthcare. Acharya Vagbata discourse in the Ritucharya Adhyaya elaborates on Swasthya Panchakarma, essential therapeutic interventions tailored to manage seasonal imbalances. These include Vamana (therapeutic emesis) for eliminating aggravated Kapha during Vasanta Ritu, Vasthi (medicated enema) for addressing aggravated Vata during Varsa Ritu, and Virechana (therapeutic purgation) for managing aggravated Pitta during Sarat Ritu. Method: A conceptual analysis was undertaken to understand the optimal timing for seasonal purification aligned with Kerala’s distinct climatic pattern. Result: Adapting Ayurvedic principles to accommodate Kerala’s specific seasonal variations ensures that these ancient practices remain relevant and effective in contemporary healthcare. By integrating local climatic insights with traditional wisdom, healthcare practitioners can optimize therapeutic outcomes and promote wellness tailored to Kerala’s seasonal rhythms. Discussion: Understanding the optimal timing for seasonal purification aligned with Kerala's distinct climatic patterns is crucial. Adapting Ayurvedic principles to accommodate Kerala's specific seasonal variations ensures that these ancient practices remain relevant and effective in contemporary healthcare. By integrating local climatic insights with traditional wisdom, healthcare practitioners can optimize therapeutic outcomes and promote wellness tailored to Kerala's seasonal rhythms.
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