UNDERSTANDING OJODUSHTI IN RELATION TO PATHOPHYSIOLOGY OF SHOCK
Published in October-December 2025 (Vol. 1, Issue 4, 2025)
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Karunya Santosh
IInd Professional BAMS Student, VPSV Ayurveda College Kottakkal
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Published in:
October-December 2025 (Vol. 1, Issue 4, 2025)- Article ID:
- KJAMR-00000048
- Paper ID:
- KJAMR-01-000048
How to Cite
Karthik & Eramangalath & Aparna.R & Santosh & K, N. (2025). UNDERSTANDING OJODUSHTI IN RELATION TO PATHOPHYSIOLOGY OF SHOCK. Kottakkal Journal of Ayurvedic Medicine And Research, 1(4), xx-xx. https://kjamr.scholarjms.com/articles/22
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A CROSS-SECTIONAL STUDY TO ASSESS KNOWLEDGE, ATTITUDE AND PRACTICE OF ANAGNI SWEDA AMONG AYURVEDA PRACTITIONERS OF KERALA
Anagni Swedana is a non-fire-based Ayurvedic sudation therapy used for relaxation, pain relief, and restoring balance according to dosha, disease and patient strength. Methods: A three-phase study was conducted. First, classical Ayurvedic texts were reviewed to identify descriptions of Swedana and Anagni Swedana. Next, the techniques were critically analyzed and classified into eight domains. Finally, a validated questionnaire survey was conducted among 104 senior Ayurveda practitioners in Kerala to assess their knowledge, attitude, and practice about Anagni sweda. Results: The review established both similarities and discrepancies in textual descriptions of Anagni Swedana. Practitioners demonstrated strong theoretical understanding but varied in actual clinical use. The survey highlighted inconsistencies in application regarding dosha, disease strength, patient condition and other contextual factors.
ASSESSMENT OF HMG-CO ENZYME A REDUCTASE INHIBITING ACTIVITY OF CHLOROGENIC ACID AND GALLIC ACID, PHENOLIC COMPOUNDS PRESENT IN THE LEAF OF AZADIRACHTA INDICA A JUSS. THROUGH MOLECULAR DOCKING
Background: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, with dysregulation of cholesterol metabolism as a key contributor. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is the rate-limiting enzyme in cholesterol biosynthesis, targeted effectively by statins. However, statins can cause adverse effects, highlighting the need for safer, natural alternatives. Gallic acid and chlorogenic acid, abundant phenolic compounds in Azadirachta indica leaves, have shown potential HMGR inhibitory activity. The objective was to evaluate the HMGR inhibitory potential of gallic acid and chlorogenic acid through molecular docking analysis, thereby elucidating their possible role as natural lipid-lowering agents. Methods: Molecular docking was performed using AutoDock Vina across seven potential binding sites of HMGR, identified from crystal structure analysis. Ligand structures were prepared from PubChem, and receptor refinement was conducted in BIOVIA Discovery Studio. Binding affinities and ligand–protein interactions were analyzed to assess inhibitory potential. Results: Binding energies for gallic acid ranged from –3.7 to –6.0 kcal/mol, with strongest binding at Site 5 (–6.0 kcal/mol), primarily stabilized by hydrophobic (Pi–Sigma, Pi–Alkyl) and electrostatic interactions (Pi–Anion, Pi–Cation). Chlorogenic acid exhibited higher binding affinities across sites (–4.3 to –7.3 kcal/mol), with Sites 5 (–7.2 kcal/mol) and 7 (–7.3 kcal/mol) showing the strongest interactions, dominated by hydrophobic alkyl–alkyl contacts. Overall, chlorogenic acid demonstrated stronger site-specific binding than gallic acid, though both showed weaker binding compared to statins. Discussion & Conclusion: Chlorogenic acid exhibits greater affinity for HMGR than gallic acid, suggesting its potential as a moderate natural HMGR inhibitor. These findings warrant further in vitro and in vivo studies to validate their cholesterol-lowering potential and explore their use as safer alternatives or adjuncts to statin therapy.
NEUROLOGICAL ACTIVITIES OF TAGARA (VALERIANA JATAMANSI JONES EX ROXB.)
Background: Valeriana jatamansi Jones (Family: Valerianaceae), a high value medicinal plant, is distributed in many countries of Asia. The species has been widely utilized in both traditional and modern medicine, with V. jatamansi being particularly valued for its insect-repelling and anthelmintic properties. Similarly, indigenous systems of medicine, particularly in Asia, have reported neurological activities like neuroprotective, sedative, anxiolytic and neurodegenerative of the species in various ailments. This review highlights on the morphological characters, phytochemical composition, medicinal uses, and pharmacological activities of V. jatamansi along with compilation of neurological activities in various articles. Materials and methods: Journals, articles and various internet publications were referred to compile the relevant information of Tagara (Valeriana jatamansi Jones) and compilation of its various neurological activities. Result and discussion: A comprehensive review of existing literature reveals that V. jatamansi exhibits a broad spectrum of biological activities, including antimicrobial, antioxidant, anti-inflammatory, cytotoxic, antitumor, and neurologically beneficial effects such as neuroprotective, neurodegenerative, anxiolytic, antidepressant, and sedative properties. Even though there are reports about the pharmacological action of medicinal plant Tagara (Valeriana jatamansi Jones) in neurological diseases, more clinical based researches are required to substantiate their role in improving the well-being of the patient. Further investigation is necessary to fully understand the molecular mechanisms of V. jatamansi, and continued research efforts can potentially lead to the development of novel, evidence-based therapies for use in contemporary medicine.
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