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Kottakkal Journal of Ayurvedic Medicine And Research

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📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

October-December 2025

Volume 1, Issue 4 - undefined 2025

Volume 1 Issue 4 Cover

Issue Details:

Volume 1 Issue 4
Published:Invalid Date

Editorial: October-December 2025

Welcome to the 2025 issue of Kottakkal Journal of Ayurvedic Medicine And Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Margaret Thompson
Editor-in-Chief
Kottakkal Journal of Ayurvedic Medicine And Research

Articles in This Issue

Showing 6 of 6 articles
Research PaperID: KJAMR-00000045

A CROSS-SECTIONAL STUDY TO ASSESS KNOWLEDGE, ATTITUDE AND PRACTICE OF ANAGNI SWEDA AMONG AYURVEDA PRACTITIONERS OF KERALA

Swethadas V P, Dr.Vinod D S, Dr Neenu Jessy Sabu

Anagni Swedana is a non-fire-based Ayurvedic sudation therapy used for relaxation, pain relief, and restoring balance according to dosha, disease and patient strength. Methods: A three-phase study was conducted. First, classical Ayurvedic texts were reviewed to identify descriptions of Swedana and Anagni Swedana. Next, the techniques were critically analyzed and classified into eight domains. Finally, a validated questionnaire survey was conducted among 104 senior Ayurveda practitioners in Kerala to assess their knowledge, attitude, and practice about Anagni sweda. Results: The review established both similarities and discrepancies in textual descriptions of Anagni Swedana. Practitioners demonstrated strong theoretical understanding but varied in actual clinical use. The survey highlighted inconsistencies in application regarding dosha, disease strength, patient condition and other contextual factors.

Anagni SwedanaKnowledge Attitude Practice survey
3,808 views
1,008 downloads

Contributors:

 Swethadas V P
,
 Dr.Vinod D S
,
 Dr Neenu Jessy Sabu
Research PaperID: KJAMR-00000046

ASSESSMENT OF HMG-CO ENZYME A REDUCTASE INHIBITING ACTIVITY OF CHLOROGENIC ACID AND GALLIC ACID, PHENOLIC COMPOUNDS PRESENT IN THE LEAF OF AZADIRACHTA INDICA A JUSS. THROUGH MOLECULAR DOCKING

Gopika Mahesh, Dr.Vivek P

Background: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, with dysregulation of cholesterol metabolism as a key contributor. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is the rate-limiting enzyme in cholesterol biosynthesis, targeted effectively by statins. However, statins can cause adverse effects, highlighting the need for safer, natural alternatives. Gallic acid and chlorogenic acid, abundant phenolic compounds in Azadirachta indica leaves, have shown potential HMGR inhibitory activity. The objective was to evaluate the HMGR inhibitory potential of gallic acid and chlorogenic acid through molecular docking analysis, thereby elucidating their possible role as natural lipid-lowering agents. Methods: Molecular docking was performed using AutoDock Vina across seven potential binding sites of HMGR, identified from crystal structure analysis. Ligand structures were prepared from PubChem, and receptor refinement was conducted in BIOVIA Discovery Studio. Binding affinities and ligand–protein interactions were analyzed to assess inhibitory potential. Results: Binding energies for gallic acid ranged from –3.7 to –6.0 kcal/mol, with strongest binding at Site 5 (–6.0 kcal/mol), primarily stabilized by hydrophobic (Pi–Sigma, Pi–Alkyl) and electrostatic interactions (Pi–Anion, Pi–Cation). Chlorogenic acid exhibited higher binding affinities across sites (–4.3 to –7.3 kcal/mol), with Sites 5 (–7.2 kcal/mol) and 7 (–7.3 kcal/mol) showing the strongest interactions, dominated by hydrophobic alkyl–alkyl contacts. Overall, chlorogenic acid demonstrated stronger site-specific binding than gallic acid, though both showed weaker binding compared to statins. Discussion & Conclusion: Chlorogenic acid exhibits greater affinity for HMGR than gallic acid, suggesting its potential as a moderate natural HMGR inhibitor. These findings warrant further in vitro and in vivo studies to validate their cholesterol-lowering potential and explore their use as safer alternatives or adjuncts to statin therapy.

Azadirachta indicagallic acidchlorogenic acidHMG-CoA reductase, molecular docking
3,675 views
1,139 downloads

Contributors:

 Gopika Mahesh
,
 Dr.Vivek P
Research PaperID: KJAMR-00000049

AYURVEDIC MANAGEMENT OF ACHARANA YONIVYAPATH WITH PRAMEHA

Gopika P, Rachana H.V

Introduction: Yoni Kandu (vaginal itching) and Pichila Srava (thick vaginal discharge) are frequently encountered gynecological complaints, often associated with Prameha in Ayurveda. Long standing Prameha often gives rise to several Upadravas (complications), among which Yoni Kandu is significant due to its impact on quality of life. The condition is aggravated by Kapha and Vata doshas and Dhatu Dushti, particularly of Rasa and Rakta. This case explores the Ayurvedic management of Yoni Kandu in Acharana Yonivyapath in a Type 1 diabetic female patient. Methods: A 28-year-old female, with Type 1 Diabetes Mellitus, presenting with 10-year history of vaginal itching and white discharge was treated with classical Ayurvedic regimen. The treatment focused on Deepana-Pachana (enhancing digestion and metabolism), Kapha-Vata Shamana (pacifying aggravated doshas), and Yoni Shodhana (cleansing of the vaginal tract). Internal medications included Chandraprabha Vati, Triphala Guggulu, Nimbashatka churna and Nishamalaki Churna. Local therapy included Yoni Prakshalana with Triphala Kashaya and application of Nimbamalahara Lepa. Dietary and lifestyle modifications were advised, along with monitoring of blood sugar levels. Results: The patient reported significant relief in symptoms within four weeks of treatment. Itching reduced substantially, discharge became minimal and non-offensive, and the patient experienced improved local comfort (in vulvar region). No adverse effects were reported. Blood glucose levels reduced drastically during the treatment period, indicating compatibility of Ayurvedic treatment with ongoing insulin therapy. Discussion: This case demonstrates the potential of Ayurvedic intervention in managing Yoni Kandu due to Acharana yonivyapath and Prameha Upadrava. By addressing Dosha imbalance and supporting metabolic health, the treatment led to symptomatic relief and improved patient well-being. Integrative management with regular monitoring can provide a holistic approach for such chronic complications in diabetic individuals. Conclusion: Ayurvedic management offers an effective and safe approach to Prameha-related Yoni Kandu. The case supports the role of dosha-specific, individualized therapy in chronic gynecological conditions associated with metabolic disorders like Type 1 Diabetes Mellitus. Further clinical studies are recommended to validate these findings.

Yoni kanduPrameha upadravaAcharana yonivyapathAyurvedic management
4,240 views
1,341 downloads

Contributors:

 Gopika P
,
 Rachana H.V
Research PaperID: KJAMR-00000047

NEUROLOGICAL ACTIVITIES OF TAGARA (VALERIANA JATAMANSI JONES EX ROXB.)

Deepika V M, Dr.Vivek P

Background: Valeriana jatamansi Jones (Family: Valerianaceae), a high value medicinal plant, is distributed in many countries of Asia. The species has been widely utilized in both traditional and modern medicine, with V. jatamansi being particularly valued for its insect-repelling and anthelmintic properties. Similarly, indigenous systems of medicine, particularly in Asia, have reported neurological activities like neuroprotective, sedative, anxiolytic and neurodegenerative of the species in various ailments. This review highlights on the morphological characters, phytochemical composition, medicinal uses, and pharmacological activities of V. jatamansi along with compilation of neurological activities in various articles. Materials and methods: Journals, articles and various internet publications were referred to compile the relevant information of Tagara (Valeriana jatamansi Jones) and compilation of its various neurological activities. Result and discussion: A comprehensive review of existing literature reveals that V. jatamansi exhibits a broad spectrum of biological activities, including antimicrobial, antioxidant, anti-inflammatory, cytotoxic, antitumor, and neurologically beneficial effects such as neuroprotective, neurodegenerative, anxiolytic, antidepressant, and sedative properties. Even though there are reports about the pharmacological action of medicinal plant Tagara (Valeriana jatamansi Jones) in neurological diseases, more clinical based researches are required to substantiate their role in improving the well-being of the patient. Further investigation is necessary to fully understand the molecular mechanisms of V. jatamansi, and continued research efforts can potentially lead to the development of novel, evidence-based therapies for use in contemporary medicine.

Tagara (Valeriana jatamansi Jones ex Roxb)Neurological activities
3,740 views
1,186 downloads

Contributors:

 Deepika V M
,
 Dr.Vivek P
Research PaperID: KJAMR-00000050

ROLE OF UTTARAVASTI IN THE MANAGEMENT OF SECONDARY AMENORRHOEA

Dr.Anitha K Vishwambharan

Background Uttaravasti is a treatment procedure which is beneficial in various gynaecological ailments and has superior qualities (1) when compared to oral medication and other therapies. This study aims to evaluate the role of Uttaravasti in the management of secondary amenorrhoea. Method This case series includes 5 patients who underwent Uttaravasti for induction of menstruation from October 2024 to September 2025 in the O.P.D of V.P.S.V Ayurveda College Hospital, Kottakkal. The outcome of the study was assessed on the basis of induction of menstruation in secondary amenorrhoea. Results In all participants, the positive outcome of treatment in the form of induction of menstruation was observed which indicated the efficacy of Uttaravasti in the less explored area of induction of menstruation. The study reveals the potential of Ayurvedic therapy to induce menstruation within a short period of time.

UttaravastiSecondary amenorrhoeainduction of menstruation
4,378 views
1,248 downloads

Contributors:

 Dr.Anitha K Vishwambharan
Research PaperID: KJAMR-00000048

UNDERSTANDING OJODUSHTI IN RELATION TO PATHOPHYSIOLOGY OF SHOCK

Uma Karthik, Sreelekshmy Eramangalath, Aparna.R, Karunya Santosh, Nihitha. K S

Ojas is the vital force that sustains life formed as an essence of all the dhatu. The decline of ojas is an inevitable sequel of any disease. Shock which is a condition that results from reduced perfusion to tissues and organ dysfunction is relatable to the 3 stages of ojakshaya as mentioned by Susrutha. Sannipatajwara which is also called as Hritaujas and its classification into 13 types can be aligned to the stages of different types of shock. The contradiction of visha and ojas and the importance of the trimarma in the pathology of ojodushti are also significant in understanding and managing ojodushti. The emergency management system has to focus on the concept of ojodushti.

OjodushtiDifferent types of shockSannipata jwara
4,101 views
1,207 downloads

Contributors:

 Uma Karthik
,
 Sreelekshmy Eramangalath
,
 Aparna.R
,
 Karunya Santosh
,
 Nihitha. K S

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